For many years, Preparation-H was used to treat wrinkles and crows feet thanks to the live yeast cells that used to go into the preparation. The cells, referred to by many as LYCD (live yeast cell derivative) are known to assist in the healing process and because of this are also used to treat burns, chapping and dry skin on general.
Unfortunately, the properties of Preparation H have recently been adjusted in the USA in 1995 in line with The Food and Drug Administration's regulations. The reformulation of its ingredients means that the preparation no longer contains the 'magical' LYCD and instead uses an approved astringent formula. However The Canadian formulation of Preparation H does infact includes the magical LYCD called BioDyne which has been removed from the formulation previously sold in the United States back in 1995. This yeast extract is believed by many to remove wrinkles from skin and heal dry, cracked, and irritated skin. Thus the Canadian formulation has acquired a market in the United States now as a skin cream.
In closing this means that any over the counter Preparation H that you buy In the United States is unlikely to help you combat fine lines and wrinkles. In fact many people argue that it no longer helps hemorrhoid sufferers either!